On-X Aortic Valve: 50% Closer to a Normal INR1

On-X Aortic Valve patients with an INR of 1.5–2.0 had a >60% reduction in bleeding events and no increase in TE compared to patients with an INR of 2.0–3.0.* All other bileaflet aortic valve anticoagulation should be managed at an INR of 2.0–3.0.2

INR vs. Event Rate3

INR vs. Event Rate

*Reduce INR after 3 months standard therapy.4


  1. Normal INR is considered 1. WHO Expert Committee on Biological Standardization, 33rd Report, World Health Organization, 1983. http://apps.who.int/iris/bitstream/10665/39217/1/WHO_TRS_687.pdf, downloaded on 06/29/2016.
  2. Nishimura et al., 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017;135:e1159–e1195.
  3. Data on file.
  4. On-X Prosthetic Heart Valve Instructions for Use.

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