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Safer With Less Warfarin

  • The only aortic mechanical heart valve FDA and CE approved with less warfarin1,*
  • >60% reduction in bleeding2
  • No increase in thromboembolism (TE)2

The On-X Aortic Valve is a newer generation heart valve made of a unique material and design characteristics compared with earlier generations of mechanical heart valves. The On-X Aortic Valve is the only mechanical valve with FDA and CE approval to be used safely with less blood thinner (warfarin).1,*  The AHA and ACC guidelines state that less blood thinner may be reasonable for patients with the mechanical On-X Aortic Valve.3 In a prospective randomized clinical trial, On-X Aortic Valve patients with a reduced blood thinner dose* had > 60% fewer bleeding events without an increase in risk of stroke.2  The On-X Aortic Valve, as a mechanical heart valve, has a much lower risk of reoperation than tissue (bioprosthetic) valves, with the additional benefit of less bleeding risk than other mechanical aortic valves because of the significantly lower amount of blood thinner required.2,*

If you are under the age of 70 years old and need aortic valve replacement, ask your doctor about the On-X Aortic Valve, the only mechanical valve that is both designed  to last a lifetime and safer with less blood thinner.3,*

*Reduce INR after 3 months standard therapy.1

On-X Heart Valves

MLENG1399.000 (2020-01)


  1. On-X Prosthetic Heart Valve Instructions for Use, https://www.onxlti.com/ifu/hv/.
  2. Puskas JD, et al. J Am Coll Cardiol 2018;71:2717-26.
  3. Nishimura R, et al. Circulation 2017;135:e1159-95.

The Basics

Medical Information

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