Strength You Can Trust

BioGlue vs. PREVELEAK® In Vitro Burst Strength

BioGlue vs. Hydrofit Burst Strength 

BioGlue Strength vs. the Competition


In vitro studies show that out of 42 anastomoses, all grafts with BioGlue were able to hold a pressure of 300 mmHg and 10 grafts were tested up to 560 mmHg without leaks.3

Patient Benefits

BioGlue’s mode of action allows it to seal the anastomoses regardless of the patient’s coagulopathic state. BioGlue is especially useful if the native tissue is calcified or fragile, because it will not only seal the anastomosis but also provide reinforcement to the suture line.

Operation Value

BioGlue is a valuable adjunct in numerous cardiac procedures such as Ventricular Assist Device implantation (outflow aortic anastomosis), aortic valve replacement (full root and aortotomies), aneurysm repair, aortic dissection repair and various other large vessel repair.


  • Reapproximates tissue layers together in complex aortic dissection repairs.
  • The adhered layers of a repaired aorta allow for more native tissue to be spared.
  • BioGlue use can reduce the number of reinforcing pledgets used in cardiac repair.1


  • Works independently of the patient’s coagulopathic state.
  • Seals tissue-graft, tissue-tissue, and graft-graft anastomoses in cardiac and vascular surgery.2
  • Covalent bonding creates a strong seal which gives surgeons the confidence to close.


  1. Coselli J, et al. Prospective Randomized Study of a Protein-Based Tissue Adhesive Used as a Hemostatic
    and Structural Adjunct in Cardiac and Vascular Anastomotic Repair Procedures. J Am Coll Surg 2003; 197:243-253.
  2. CryoLife, Inc. Data on File. PMA #P010003, December 2001.
  3. Anastomoses were made between cryopreserved human saphenous vein segments and coronary arteries in vitro on 12 intact bovine heart using BioGlue as the primary means of joining and sealing the vessels. (This was done to assess the feasibility of a glued anastomosis to facilitate attaching coronary artery bypass grafts during beating heart bypass procedures. There has been no human clinical use of the BioGlue in this application). A total of 42 anastomoses were evaluated for anastomotic burst strength.

    All grafts held a pressure of 300 mm HG; 10 grafts were tested up to 560 mm Hg without leaks. All anastomoses were patent with no intraluminal BioGlue detected.

BioGlue Surgical Ahesive

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