On August 7, 2014, CryoLife announced that it has acquired the distribution rights for PhotoFix™ DECELLULARIZED BOVINE PERICARDIUM from Genesee Biomedical, Inc.

PhotoFix is a proven, clinically effective tissue substitute that is biocompatible without toxicity. It is derived from bovine pericardium, a material known for reliable consistency and strength with handling characteristics similar to autologous pericardium, and has undergone a dye-mediated photo-oxidation fixation process.

Key Steps of the PhotoFix Treatment Process

Fixation of cardiovascular tissues with dye-mediated photo-oxidation results in a stabilized material that is non-immunogenic, and non-cytotoxic, yet maintains natural physical properties and biomechanical integrity.

The bovine pericardial tissue is incubated in a photooxidative dye, followed by exposure to light at specific wavelengths. The light is selectively absorbed by the dye to promote crosslinking and stabilization of the internal collagen structure. Unlike glutaraldehyde treated tissue, photo-fixation uses no “external chemistry” that could be cytotoxic. The reduction of toxic by-products also reduces the sites where calcium can bind to tissue.


PhotoFix is indicated for use in:

  • Atrial Repair

  • Ventricle Repair

    • Ventricular Aneurysm

    • DOR or Left Ventricular Reconstruction (LVR) for Ischemic Cardiomyopathy

    • Repair of Free Wall of LV (MI)

    • Left Ventricular Outflow Tract (LVOT)

  • Great Vessel Repair

    • Aortic Arch

    • Aortic Root

    • Left Ventricular Outflow Tract (LVOT)

  • Congenital Defects

    • Atrial Septal Defect (ASD)

    • Ventricle Septal Defect (VSD)

    • Tetralogy of Fallot (TOF)

  • Pericardial Closure

PhotoFix Advantages Clinical Expectations
Dye-mediated photooxidation technology No chemical crosslinking to promote cytotoxicity or mutagenic response; Dye-mediated photooxidation provides a simple alternative without the “side effects” of glutaraldehyde
Reduced risk of calcification PhotoFix performs comparably to autologous pericardium, and glutaraldehyde treated bovine pericardium is prone to calcification, especially in young children
Host endothelialization PhotoFix material supports cell adhesion and growth without any immunogenicity
Biocompatibility PhotoFix material is non-immunogenic, and non-cytotoxic, yet maintains natural physical properties and biomechanical integrity
Potential to reduce epicardial adhesions PhotoFix is biocompatible and non immunogenic which offers the potential to reduce the likelihood of epicardial reactions and the formation of retrosternal adhesions in pericardial closures

How Supplied

The PhotoFix Pericardial Patch measures 6cm x 8cm and is supplied sterile and non-pyrogenic in a sealed container with 22% buffered ethanol solution. The package is designed to facilitate convenient, aseptic transfer of the pericardium to the sterile field, with no rinsing required.

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  1. Myers PO, et al. J Thorac Cardiovasc Surg 2010; 140:836-844
  2. Schmidt CE, Baier JM. Biomaterials 2000; 21:2215-2231